Cell Culture Media, Supplements, and Reagents
Medchemexpress LLC Oxcarbazepine | 28721-07-5 | MFCD00865307 | 99.9% | C15H12N2O2 | 500 MG
Oxcarbazepine is a sodium channel blocker with anti-cancer and anticonvulsant effects. It significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines.
- Significantly inhibits glioblastoma cell growth
- Induces apoptosis or G2/M arrest in glioblastoma cell lines
- Exhibits anticonvulsant effects
Medchemexpress LLC Cilastatin-15N,d3 | 2738376-83-3 | 99.7% | C16H23D3N15NO5S | 1 MG
Cilastatin-15N,d3 is a 15N-labeled and deuterium-labeled form of Cilastatin. Cilastatin (MK0791) acts as a reversible, competitive inhibitor of renal dehydropeptidase I, with an IC50 of 0.1 μM. It also inhibits the bacterial metallo-β-lactamase enzyme CphA at an IC50 of 178 μM. Cilastatin is utilized as an antibacterial adjunct.
- This compound serves as a tracer.
- It can be used as an internal standard for quantitative analysis through techniques such as NMR, GC-MS, or LC-MS.
- The incorporation of stable heavy isotopes (hydrogen, carbon, and other elements) into drug molecules is primarily for quantitation during drug development.
- Deuteration, in particular, has shown potential to influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Cilazapril monohydrate | 92077-78-6 | MFCD00865788 | 99.9% | C22H33N3O6 | 5 MG
Cilazapril monohydrate is an orally active prodrug of the angiotensin-converting enzyme (ACE) inhibitor Cilazaprilat. It reduces plasma ACE activity and can be used in the research of hypertension (including essential and renal hypertension) and congestive heart failure.
- Orally active prodrug of Cilazaprilat
- Reduces plasma ACE activity
- Applicable in research for hypertension (essential and renal) and congestive heart failure
- Evokes a maximum degree of plasma ACE inhibition (-76%) in rats
- Dose-dependently reduces plasma ACE activity and pressor response to angiotensin in cats
- Gradually reduces blood pressure in dogs with volume-depleted renal hypertension
- Decreases blood pressure, reduces heart weight to body weight ratio, and improves postischemic myocardial function in hyperthyroid rats
Medchemexpress LLC Carbetocin (acetate) | 1631754-28-3 | 99.6% | 1048.21 | 50 MG
Carbetocin acetate is an oxytocin (OT) analogue and an oxytocin receptor agonist with a Ki of 7.1 nM. It shows high affinity to the chimeric N-terminus (E1) of the oxytocin receptor (Ki=1.17 μM). This compound has potential for research related to postpartum hemorrhage. It can cross the blood-brain barrier and exhibits antidepressant-like activity by activating oxytocin receptors in the CNS.
- Oxytocin receptor agonist
- Oxytocin (OT) analogue
- Potential for postpartum hemorrhage research
- Can cross the blood-brain barrier
- Produces antidepressant-like activity via activation of oxytocin receptors in the CNS
- Higher stability and longer duration of action compared to oxytocin
Medchemexpress LLC Azithromycin (hydrate) | 117772-70-0 | 98.0% | 785.02 | 25 MG
Azithromycin hydrate is a macrolide antibiotic effective against various bacterial infections. This compound has also demonstrated antiviral activity against HCoV-229E and HCoV-OC43 in vitro, and exhibits immunomodulatory effects by enhancing rhinovirus-induced IFNβ expression and lowering MMP-9 levels. It is also explored for its potential in autophagy pathways and as an antiparasitic agent. Intended for research use only, this product is not for medical or patient use.
- Functions as a macrolide antibiotic
- Shows antiviral activity against specific coronaviruses
- Enhances antiviral immune responses in bronchial epithelial cells
- Reduces inflammatory markers like MMP-9 levels
- Has potential applications in autophagy and as an antiparasitic
- Available for various research applications and compound screening
- Used in numerous clinical trials for diverse conditions
Medchemexpress LLC Vancomycin (hydrochloride) | 1404-93-9 | 99.47% | 1450 Da | 10 G
Vancomycin hydrochloride is an antibiotic used for treating bacterial infections. It works by inhibiting the second stage of cell wall synthesis in susceptible bacteria. Additionally, Vancomycin alters the permeability of the cell membrane and selectively inhibits ribonucleic acid synthesis. It is a large glycopeptide compound active against many Gram-positive bacteria like Staphylococcus aureus, Staph. epidermidis, Str. agalactiae, Str. bovis, Str. mutans, viridans streptococci, and enterococci.
- Antibiotic for the treatment of bacterial infections.
- Inhibits the second stage of cell wall synthesis of susceptible bacteria.
- Alters cell membrane permeability and selectively inhibits ribonucleic acid synthesis.
- Glycopeptide antibiotic.
- Active against various Gram-positive bacteria.
Medchemexpress LLC Anisomycin | 22862-76-6 | 99.8% | 265.31 | 100 MG
Anisomycin is a potent protein synthesis inhibitor that interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system. It is also a JNK activator, which increases phospho-JNK, and a bacterial antibiotic.
- Potent protein synthesis inhibitor
- Interferes with protein and DNA synthesis
- Inhibits peptidyl transferase or the 80S ribosome system
- JNK activator
- Bacterial antibiotic
Medchemexpress LLC Mk-28 | 864388-65-8 | 99.88% | 396.44 | 100 MG
MK-28 is a potent and selective PERK activator that demonstrates significant pharmacokinetic properties and high blood-brain barrier (BBB) penetration in mice. It has been shown to rescue cells from ER stress-induced apoptosis in vitro and improve systemic function and survival in R6/2 mice, an animal model for Huntington's disease. MK-28 also enhances motor and executive functions and delays the onset of death in R6/2 mice without causing toxicity.
- Potent and selective PERK activator
- Exhibits significant pharmacokinetic properties
- High blood-brain barrier (BBB) penetration in mice
- Rescues cells from ER stress-induced apoptosis in vitro
- Improves systemic function and survival in R6/2 mice
- Enhances motor and executive functions and delays death onset in R6/2 mice
- Activates EIF2AK4 (GCN2)
- Has little or no effect on EIF2AK1 (HRI) or EIF2AK2 (PKR)
Medchemexpress LLC Acyclovir-d4 | 1185179-33-2 | 98.66% | 229.23 | 1 MG
Acyclovir-d4 is the deuterium labeled Acyclovir. Acyclovir is a guanosine analogue and an orally active antiviral agent. It inhibits HSV-1, HSV-2, and varicella-zoster virus, interfering with viral DNA polymerization.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
